1,1-Dimethylethyl (betaS)-beta-aminobenzenepropanoate → Methyl (S)-3-amino-3-phenylpropanoate

HRID 1823833ノート

反応式

HRID 1823833 の反応式
[NH2:1][C@H:2]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:3][C:4]([O:6][C:7](C)(C)C)=[O:5]>Cl>[CH3:7][O:6][C:4](=[O:5])[CH2:3][C@H:2]([NH2:1])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

参加物

3

反応物 1

HCID 70210931,1-Dimethylethyl (betaS)-beta-aminobenzenepropanoate

生成物 1

HCID 788099Methyl (S)-3-amino-3-phenylpropanoate

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

t-Butyl (3S)-3-amino-3-phenylpropanoate (1.0 g, 4.97 mmol) was dissolved in methanolic hydrochloric acid (2.25M, 25 ml). The reaction mixture was heated under reflux for 3 hours, after which time the solvent was evaporated under reduced pressure and the residue basified with aqueous saturated sodium carbonate solution. The product was then extracted using dichloromethane (x2), the combined organic layers were dried (MgSO4), filtered and the solvent removed under reduced pressure to afford the title compound as a white solid, 778 mg.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 3 hours
  3. customafter which time the solvent was evaporated under reduced pressure
  4. extractionThe product was then extracted
  5. dry with materialthe combined organic layers were dried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-7b7c978dde6f45a9a766c891608f96e8
出典データセット
uspto-grants-2006_05
特許番号
US07041667B1

反応ノート

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