2-Amino-4'-methoxyacetophenone → 2-(3-Chloro-thiophen-2-yl)-5-(4-methoxy-phenyl)-oxazole

HRID 1823882

反応式

HRID 1823882 の反応式
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7](Cl)=[O:8].[NH2:10][CH2:11][C:12]([C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=O>>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[O:8][C:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:11][N:10]=1

参加物

3

反応物 2

HCID 4128892-Amino-4'-methoxyacetophenoneHCID 27358243-Chlorothiophene-2-carbonyl chloride

生成物 1

HCID 221479072-(3-Chloro-thiophen-2-yl)-5-(4-methoxy-phenyl)-oxazole

実験手順

3-Choloro-thiophene-2-carboxylic acid-[2-(4-methoxy-phenyl)-2-oxo-ethyl]-amide: The title compound was prepared from 3-chloro-thiophene-2-carbonyl chloride and 2-amino-4′-methoxyacetophenone by a procedure similar to Example 93a as an orange solid. 1H NMR (DMSO-d6): 8.30 (s, NH), 8.02 (d, J=9.0 Hz, 1H), 7.89 (d, J=6.6 Hz, 2H), 7.20 (d, J=6.0 Hz, 2H), 7.10 (d, J=8.7 Hz, 1H), 4.80 (d, J=5.4 Hz, 2H), 3.86 (s, 3H).

出典と根拠

ORDレコード
ord-261f8eb3dbee48e9acbcad0174d2460d
出典データセット
uspto-grants-2006_05
特許番号
US07041685B2

関連ノート

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