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3,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine → 5-bromo-3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,6-diethyl-N-(5-methoxy 1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine | HCID 22147477 | — |
| 反応物 | (1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol | HCID 58583245 | — |
| 生成物 | 5-bromo-3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine | HCID 22147393 | — |
反応手順
Following the procedure for the preparation of (1R,2S)-1-[(5-bromo-3,6-diethylpyrazin-2-yl)amino]-2,3-dihydro-1H-inden-2-ol but substituting 3,6-diethyl-N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)pyrazin-2-amine and making non-critical variations provided the title compound as a oil: 1H NMR (400 MHz, CDCl3) δ) 7.18, 6.97, 6.79, 5.37, 4.53, 2.87–2.76, 2.70–2.64, 2.54, 2.01–1.86, 1.35–1.24; HRMS (FAB) calcd for C19H24BrN3O+H 390.1181, found 390.1186.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07041672B2 |
| 出典データセット | uspto-grants-2006_05 |
| ORD ID | ord-26240153481e4401b0f1d22cc5c3d0aa |
| 出典メモ | uspto-grants-2006_05 |