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Famciclovir → 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Famciclovir | HCID 3324 | — |
| 反応物 | 6,8-Dichloro-9H-purin-2-amine | HCID 5464677 | — |
| 生成物 | 9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine | HCID 11025564 | — |
反応手順
Moreover, U.S. Pat. No. 5,138,057 discloses a process for preparing 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine of Formula (I), in which 2-amino-6,8-dichloropurine of Formula (X) is reacted with 2-acetoxymethyl-4-halobut-1-yl-acetate of Formula (VII) to give 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-amino-6,8-dichloropurine of Formula (XI) which is then reduced under a pressurized condition in the presence of palladium, as shown in Scheme 3 below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07041823B2 |
| 出典データセット | uspto-grants-2006_05 |
| ORD ID | ord-9366565ebc55455a8cd243320e61ab02 |
| 出典メモ | uspto-grants-2006_05 |