Bromine → alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

HRID 1824497

反応式

HRID 1824497 の反応式
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[F:1])=[O:15]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 69375838HCID 69375838、化合物

生成物 1

HCID 22015593alpha-Bromo-2'-fluoro-4'-chloropropoxyacetophenone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of the product of Step A (2.3 g) in ether (10 mL) was treated with bromine (0.51 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (40 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (40 mL). The combined organic layers were washed with a fresh portion of water (50 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (3.1 g).

後処理

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (40 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (50 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-14adc6fc786347cfb16b7340c71444a9
出典データセット
uspto-grants-2006_05
特許番号
US07041827B2

関連ノート

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