Bromine → alpha-Bromo-2'-methyl-4'-chloropropoxyacetophenone

HRID 1824501

反応式

HRID 1824501 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])[CH:5]=[CH:4][C:3]=1[C:13](=[O:15])[CH3:14].[Br:16]Br.C(=O)(O)[O-].[Na+]>CCOCC>[Br:16][CH2:14][C:13]([C:3]1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH2:10][CH2:11][Cl:12])=[CH:7][C:2]=1[CH3:1])=[O:15]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 693770792'-Methyl-4'-chloropropoxyacetophenone

生成物 1

HCID 22015662alpha-Bromo-2'-methyl-4'-chloropropoxyacetophenone

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A solution of the product of Step A (9.33 g) in ether (42 mL) was treated with bromine (2.1 mL) and the mixture stirred for approximately 17 hours. The mixture was slowly poured into saturated sodium bicarbonate solution (100 mL) and then the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (100 mL). The combined organic layers were washed with a fresh portion of water (100 mL), dried over magnesium sulfate, filtered and evaporated to give the title compound (11 g).

後処理

  1. customthe organic layer was separated
  2. washThe aqueous layer was washed with a fresh portion of ether (100 mL)
  3. washThe combined organic layers were washed with a fresh portion of water (100 mL)
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-e7b019653ccd4007bd234cfdeb69effc
出典データセット
uspto-grants-2006_05
特許番号
US07041827B2

関連ノート

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