2-Amino-4-methylpyridine → 2-(4'-Chloropropoxy-2'-methylphenyl)-7-methylimidazo[1,2-a]pyridine

HRID 1824502

反応式

HRID 1824502 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][Cl:15])=[CH:7][C:6]=1[CH3:16])=O.[NH2:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]=1>C(O)C.CO.ClCCl>[Cl:15][CH2:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[N:17]=[C:18]3[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][N:19]3[CH:2]=2)=[C:6]([CH3:16])[CH:7]=1

参加物

5

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 22015662alpha-Bromo-2'-methyl-4'-chloropropoxyacetophenone

生成物 1

HCID 220156392-(4'-Chloropropoxy-2'-methylphenyl)-7-methylimidazo[1,2-a]pyridine

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 21226129Dichloromethane methanol溶媒

実験手順

A solution of the product of Step B (6.77 g) and 2-amino-4-picoline (2.4 g) in ethanol (22 mL) was heated at 72° C. for 10 hours. The reaction mixture was cooled to ambient temperature and dissolved in methanol/dichloromethane and treated with Dowex® 550A basic resin until the pH of the mixture was 7. The resin was removed via filtration and the filtrate evaporated. The title compound was precipitated from ethyl acetate upon addition of hexanes and used without further purification.

後処理

  1. customThe resin was removed via filtration
  2. customthe filtrate evaporated
  3. customThe title compound was precipitated from ethyl acetate upon addition of hexanes
  4. customused without further purification

出典と根拠

ORDレコード
ord-422677b8be984d218adb610e1e5b4875
出典データセット
uspto-grants-2006_05
特許番号
US07041827B2

関連ノート

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