Piperidine → 4-Piperidinylbut-1-ene

HRID 1824516

反応式

HRID 1824516 の反応式
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1>>[N:6]1([CH2:7][CH2:8][CH:9]=[CH2:10])[CH2:11][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 8082PiperidineHCID 21241Homoallyl bromide

生成物 1

HCID 45622824-Piperidinylbut-1-ene収率 93.4%

実験手順

A mixture of 1-bromo-3-butene (1.35 g, 10 mmol) and piperidine (1.70 g, 20 mmol) neat was refluxed under nitrogen atmosphere for 3 h. Cooled to RT, filtered and dissolved into ethyl ether (40 mL). Then solution was washed with water (2×30 mL) and dried over anhydrous Na2SO4, filtered and evaporated to dryness to yield 1.3 g (74.15%) oily 1-piperidyl-3-butene.

後処理

  1. temperatureneat was refluxed under nitrogen atmosphere for 3 h
  2. filtrationfiltered
  3. dissolutiondissolved into ethyl ether (40 mL)
  4. washThen solution was washed with water (2×30 mL)
  5. dry with materialdried over anhydrous Na2SO4
  6. filtrationfiltered
  7. customevaporated to dryness

出典と根拠

ORDレコード
ord-93ed809aea91417888e91412cff47150
出典データセット
uspto-grants-2006_05
特許番号
US07041827B2

関連ノート

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