4-Vinylbenzaldehyde → 4-Vinylbenzaldehyde

HRID 1824619

反応式

HRID 1824619 の反応式
[C:1]([OH:4])(=S)[CH3:2].[CH:5]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1)=[CH2:6]>CN(C=O)C>[CH:10]([C:9]1[CH:8]=[CH:7][CH:5]=[CH:6][C:2]=1[CH:1]=[O:4])=[CH2:11].[CH:5]([C:7]1[CH:14]=[CH:13][C:10]([CH:11]=[O:12])=[CH:9][CH:8]=1)=[CH2:6]

参加物

5

反応物 2

HCID 393894-VinylbenzaldehydeHCID 178418634HCID 178418634、化合物

生成物 2

HCID 393894-VinylbenzaldehydeHCID 39391Benzaldehyde, 2-ethenyl-

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Aldehyde 11 was synthesized by radical addition (Lub et al. (1997) Liebigs Ann. Recueil, 2281–2288) of thioacetic acid to 4-vinylbenzaldehyde. Vinyl benzaldehyde was synthesized by the procedure of Ren et al. (1993) Bull. Chem. Soc. Jpn. 66: 1897–1902 with the following changes: The addition of DMF was performed at a 38 mmol scale at 0° C. Purification by column chromatography (silica, Et2O/hexanes, 1:3) afforded 4-vinylbenzaldehyde in 60% yield (FIG. 37).

後処理

  1. customwas performed at a 38 mmol scale at 0° C
  2. customPurification by column chromatography (silica, Et2O/hexanes, 1:3)

出典と根拠

ORDレコード
ord-7634c165a21d451eaed7b282210961fa
出典データセット
uspto-grants-2006_05
特許番号
US07042755B1

関連ノート

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