Serinol → 1,3-Propanediol, 2-[(6-methoxy-3-nitro-2-pyridinyl)amino]-
反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[C:4]([O:11][CH3:12])[N:3]=1.[NH2:13][CH:14]([CH2:17][OH:18])[CH2:15][OH:16]>C(O)C>[CH3:12][O:11][C:4]1[N:3]=[C:2]([NH:13][CH:14]([CH2:17][OH:18])[CH2:15][OH:16])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=1参加物
4
実験手順
4 g (0.0212 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 40 ml of ethanol and 3.86 g (0.042 mol) of 2-aminopropane-1,3-diol are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 4.54 g of yellow powder are obtained, ie a yield of 88.2%.
後処理
- temperatureThe mixture is refluxed for 2 hours
- stirringwith stirring
- customThe precipitate formed
- filtrationis filtered off by suction
- customdried under vacuum to constant weight
出典と根拠
- ORDレコード
- ord-48422e4d7841428d9f78bb83863d12f2
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07044987B2
反応ノート
読み込み中…