Phosphorus oxychloride → HCID 11196721、化合物

HRID 1824720

反応式

HRID 1824720 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](O)[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:21])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([Cl:21])[C:15]3[CH2:14][CH2:13][CH2:12][CH2:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 178517489HCID 178517489、化合物

生成物 1

HCID 11196721HCID 11196721、化合物

実験手順

8.0 g of 2-(4-chlorophenyl)-4-hydroxy-5,6,7,8-tetrahydroquinazoline were heated to 100° C. in 10 ml of phosphorus oxychloride. After 3 hours, the cooled solution was carefully poured onto ice water. The crystalline product was filtered off with suction, washed well with water and dried in vacuo at room temperature. Yield: 6.2 g; m.p.: 121° C.

後処理

  1. additionthe cooled solution was carefully poured onto ice water
  2. filtrationThe crystalline product was filtered off with suction
  3. washwashed well with water
  4. customdried in vacuo at room temperature

出典と根拠

ORDレコード
ord-17378f48516545b6a8122404210c0143
出典データセット
uspto-grants-2006_05
特許番号
US07045526B2

関連ノート

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