Hydrochloric Acid → HCID 135518082、化合物

HRID 1824812ノート

反応式

HRID 1824812 の反応式
C[O:2][C:3]1[CH:19]=[CH:18][C:6]2[N:7]=[C:8]([C:10]3[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=3)[S:9][C:5]=2[CH:4]=1.Cl.N1C=CC=CC=1.Cl>>[OH:16][C:13]1[CH:12]=[CH:11][C:10]([C:8]2[S:9][C:5]3[CH:4]=[C:3]([OH:2])[CH:19]=[CH:18][C:6]=3[N:7]=2)=[CH:15][CH:14]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 10016034HCID 10016034、化合物HCID 10176127Pyridinium chloride

生成物 1

HCID 135518082HCID 135518082、化合物収率 100%

実験手順

6-Methoxy-2-(4-methoxy-phenyl)-benzothiazole (134 mg, 0.49 mmol) and pyridine hydrochloride (1.34 g, 11.6 mmol) were heated to 200° C. under nitrogen for 40 min, and then cooled to room temp. Reaction was poured cautiously into aqueous hydrochloric acid (1M) and extracted with ethyl acetate. Ethyl acetate extracts were washed with: 1) hydrochloric acid (1.0M), 2) saturated brine and concentrated in vacuo. Residue was washed with ether/hexane (1:4), dried under vacuum yielding the title compound (119 mg, 100%) as a yellow solid. MH+=244 The starting 6-Methoxy-2-(4-methoxy-phenyl)-benzothiazole was prepared as follows:

後処理

  1. customReaction
  2. extractionextracted with ethyl acetate
  3. washEthyl acetate extracts were washed with: 1) hydrochloric acid (1.0M), 2) saturated brine
  4. concentrationconcentrated in vacuo
  5. washResidue was washed with ether/hexane (1:4)
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-e98bcbdd54b24dee92f2a56c1bb7b957
出典データセット
uspto-grants-2006_05
特許番号
US07045539B2

反応ノート

読み込み中…