Oxalic Acid → 2-(5-Fluorobenzofur-7-yl)-1-aminoethane oxalate

反応式

[F:1][C:2]1[CH:3]=[C:4]([CH:11](C)[C:12]([NH2:14])=O)[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1.FC1C=C(CCN)C2OC=CC=2C=1.B.[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32]>>[C:30]([OH:35])(=[O:34])[C:31]([OH:33])=[O:32].[F:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][NH2:14])[C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1

参加物

反応物 4

HCID 971Oxalic Acid

HCID 6331Borane

HCID 221448132-(5-Fluorobenzofur-7-yl)propionamide

HCID 221448242-(5-Fluorobenzofur-7-yl)-1-aminoethane

生成物 1

HCID 221448232-(5-Fluorobenzofur-7-yl)-1-aminoethane oxalate

実験手順

Beginning with 2-(5-fluorobenzofur-7-yl)propionamide (EXAMPLE 39), 2-(5-fluorobenzofur-7-yl)-1-aminoethane was prepared by borane reduction essentially as described in EXAMPLE 39. This amine was treated with oxalic acid to provide the title compound.