Hydrochloric Acid → (R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

HRID 1825044ノート

反応式

HRID 1825044 の反応式
C(OC(=O)[NH:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10])(C)(C)C.[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH2:7][C@H:8]([C:11]1[CH:20]=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=1)[CH2:9][OH:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57419701(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 57462036(R)-2-Amino-2-(naphthalen-2-yl)ethanol hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

(R)-(2-Hydroxy-1-naphthalen-2-yl-ethyl)-carbamic acid tert-butyl ester (2.5 g) and 9 mL of 4 N HCl in ethyl acetate at 50° C. was stirred for 2 h. After concentration, the residue was neutralized with 10 N NaOH and extracted with methylene chloride. The organic layer was washed with brine, dried over Na2SO4, and concentrated to give the title compound (1.2 g) as a solid which was used in the next step without further purification.

後処理

  1. concentrationAfter concentration
  2. extractionextracted with methylene chloride
  3. washThe organic layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-062f6ba3c58045ff9ccff54ef3a87135
出典データセット
uspto-grants-2006_05
特許番号
US07045551B2

反応ノート

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