2-Bromopyrimidine → HCID 22143619、化合物

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([Sn](C)(C)C)[S:10][C:3]=12.Br[C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:16]3[N:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[S:10][C:3]=12

参加物

反応物 2

HCID 783452-Bromopyrimidine

HCID 221434977-Chloro-2-(trimethylstannyl)thieno[3,2-b]pyridine

生成物 1

HCID 22143619HCID 22143619、化合物収率 40.4%

実験手順

This material was prepared by coupling 7-chloro-2-(trimethylstannyl)thieno[3,2-b]pyridine 39a (0.218 g, 0.66 mmole) with 2-bromopyrimidine (0.104 g, 0.66 mmole) using tereakis(triphenylphosphine) palladium(0) (31 mg) as catalyst in a manner as previously described for example 39b to give a white solid (0.066 g, 40%). 1H NMR (300 MHz, CDCl3) δ 8.76 (2H, d, J=4.90 Hz), 8.57 (1H, d, J=5.1 Hz), 8.41 (1H, s), 7.26 (1H, d, J=5.1 Hz), 7.20 (1H, m); ESIMS (MH+): 248.00.

後処理

customThis material was prepared

出典と根拠

ORDレコード: ord-2f7e4ee624a645b9a10100d06f9004b6
出典データセット: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07045528B2

反応ノート

読み込み中…

参加物