Boron tribromide → 2-Ethyl 6-hydroxybenzo[b]thiophene

反応式

[CH2:1]([C:3]1[S:7][C:6]2[CH:8]=[C:9]([O:12]C)[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].B(Br)(Br)Br>>[CH2:1]([C:3]1[S:7][C:6]2[CH:8]=[C:9]([OH:12])[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

参加物

反応物 2

HCID 25134Boron tribromide

HCID 221436902-Ethyl-6-methoxybenzo[b]thiophene

生成物 1

HCID 221435082-Ethyl 6-hydroxybenzo[b]thiophene収率 82%

実験手順

This material was prepared from 2-ethyl-6-methoxybenzo[b]thiophene 134a (2.30 g, 12 mmole) by treatment with BBr3 in a manner as previously described for example 1d to give a white solid (1.75 g, 82%). 1H NMR (DMSO-d6) δ 9.43 (1H, s), 7.48 (1H, d, J=8.5 Hz), 7.16 (1H, d, J=2.2 Hz), 6.95 (1H, s), 6.78 (1H, dd, J=2.2, 8.5 Hz), 2.81 (2H, q, J=7.5 Hz), 1.26 (3H, t, J=7.5 Hz).

出典と根拠

ORDレコード: ord-ccaa8a0344ac4cf28bccc8544f087d0a
出典データセット: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07045528B2

反応ノート

読み込み中…

参加物