1,3-dimethyl-1H-indole-2-carbaldehyde → HCID 22139054、化合物

HRID 1826001ノート

反応式

HRID 1826001 の反応式
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH:25]=O)=[CH:18][N:19]2[CH3:24].CN1C2C(=CC=CC=2)C(C)=C1C=O>>[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH2:25][NH:6][CH3:5])=[CH:18][N:19]2[CH3:24]

参加物

4

反応物 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 221391304-chloro-1-methyl-1H-indole-3-carboxaldehyde

生成物 1

HCID 22139054HCID 22139054、化合物収率 78%

実験手順

According to the procedure of Preparation 13 (c), except substituting 4-chloro-1-methyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (1.75 g, 78%) was obtained as a yellow solid: MS (ES) m/e 209.0 (M+H)+.

出典と根拠

ORDレコード
ord-fe863af5b68042b3ac279f2cefb48c9f
出典データセット
uspto-grants-2006_05
特許番号
US07049310B2

反応ノート

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