Toluene → 1-(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanone

反応式

[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1.[C:12]1(C)C=CC=CC=1>>[NH2:1][C:2]1[C:7]([C:8](=[O:9])[CH3:12])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1

参加物

反応物 2

HCID 1140Toluene

HCID 220531[4-Amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol

生成物 1

HCID 111830131-(4-Amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanone収率 72%

実験手順

By substituting 1-(4-amino-2-methylsulfanyl-pyrimidin-5-yl)-ethanol (Example 34) for (4-amino-2-methylsulfanyl-pyrimidin-5-yl)-methanol in Example 3 and conducting the reaction at 80° C. in toluene, 3.74 g (72%) of the product as a solid is obtained.

出典と根拠

ORDレコード: ord-17c280d8d11447929951c2603eef6d8b
出典データセット: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07053070B2

反応ノート

読み込み中…