3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde → 3-[3,5-Dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-4-thiazol-2-yl-1,3-dihydroindol-2-one
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH2:8][C:9](=[O:15])[NH:10]2.[CH3:16][C:17]1[C:21]([C:22]([N:24]2[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]2)=[O:23])=[C:20]([CH3:31])[NH:19][C:18]=1[CH:32]=O>>[CH3:16][C:17]1[C:21]([C:22]([N:24]2[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]2)=[O:23])=[C:20]([CH3:31])[NH:19][C:18]=1[CH:32]=[C:8]1[C:7]2[C:11](=[CH:12][CH:13]=[CH:14][C:6]=2[C:2]2[S:1][CH:5]=[CH:4][N:3]=2)[NH:10][C:9]1=[O:15]参加物
3
実験手順
4-Thiazol-2-yl-1,3dihydro-indol-2-one (54 mg, 0.25 mmol) was condensed with 3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde (69 mg, 0.275 mmol) to give the title compound.
出典と根拠
- ORDレコード
- ord-f00833bfbdd54128ac030eea66fa60a8
- 出典データセット
- uspto-grants-2006_05
- DOI