Hydrogen Peroxide → 6-Fluoroquinoxaline-2-carboxylic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH:12]=[O:13])[CH:6]=[N:5]2.[OH:14]O>C(O)=O.Cl>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]([OH:14])=[O:13])[CH:6]=[N:5]2参加物
5
実験手順
Using the method of Dodd (Synthesis, 1993, 295–297), a solution of 6-fluoroquinoxaline-2-carboxaldehyde (71 mg, 0.4 mmol) in formic acid (2 mL) was cooled in an ice bath and treated with hydrogen peroxide (2 mL of 30%). The reaction was stirred in the ice bath for 3 hours. After this time the reaction mixture was diluted with 10% HCl (25 mL) and extracted with dichloromethane (4×25 mL). The combined organic extracts were dried over anhydrous MgSO4, filtered and concentrated to afford 35 mg (45%) of 6-fluoroquinoxaline-2-carboxylic acid.
後処理
- customthe method of Dodd (Synthesis, 1993, 295–297)
- extractionextracted with dichloromethane (4×25 mL)
- dry with materialThe combined organic extracts were dried over anhydrous MgSO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-86d4cae0c6ae4001baedc53d507ef9d9
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07053104B2
反応ノート
読み込み中…