Hydrochloric Acid → HCID 69661986、化合物
反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][C:8]2=[O:11])=[CH:4][CH:3]=1.Cl.[O:13]1CCOCC1>>[ClH:1].[NH2:7][CH2:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:10][C:9]=1[C:8]([OH:11])=[O:13]参加物
4
反応条件
- 温度
- 110 °C
実験手順
A mixture of 6-chloro-2,3-dihydro-isoindol-1-one (0.115 g, 0.68 mmol) and 6M hydrochloric acid (8 ml) in dioxan (1 ml) was heated to 110° C. for 18 hours. After cooling to room temperature the solid was filtered off and dried in vacuo to give the title compound (0.0055 g, 4%) as a beige solid.
後処理
- temperatureAfter cooling to room temperature the solid
- filtrationwas filtered off
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-b3ab6d55020f42c5a286a5250f02551b
- 出典データセット
- uspto-grants-2006_05
- 特許番号
- US07053122B2
反応ノート
読み込み中…