Hydrochloric Acid → 2-Aminomethyl-3-bromo-benzoic acid hydrochloride salt

HRID 1826992ノート

反応式

HRID 1826992 の反応式
C(OC([NH:8][CH2:9][C:10]1[C:18]([Br:19])=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13])=O)(C)(C)C.[ClH:20]>C(OCC)C>[ClH:20].[NH2:8][CH2:9][C:10]1[C:18]([Br:19])=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 221368283-Bromo-2-(((tert-butoxycarbonyl)amino)methyl)benzoic acid

生成物 1

HCID 696626982-Aminomethyl-3-bromo-benzoic acid hydrochloride salt収率 13%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-(tert-Butoxy carbonylamino-methyl)-3-bromo-benzoic acid (0.188 g, 0.57 mmol) in 2M HCl in diethyl ether (10 ml) was stirred at room temperature for 18 hours. The solvent was removed by evaporation under reduced pressure. The solid was diluted with ethyl acetate/dioxan (1:1) (10 ml) and stirred at room temperature for 1.5 hours. The solid was filtered off and dried to give the title compound (0.02 g, 13%) as a white solid.

後処理

  1. customThe solvent was removed by evaporation under reduced pressure
  2. additionThe solid was diluted with ethyl acetate/dioxan (1:1) (10 ml)
  3. stirringstirred at room temperature for 1.5 hours
  4. filtrationThe solid was filtered off
  5. customdried

出典と根拠

ORDレコード
ord-b774302d34564f4f959dcda875fed9f7
出典データセット
uspto-grants-2006_05
特許番号
US07053122B2

反応ノート

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