HCID 10155464、化合物 → HCID 9858528、化合物

HRID 1827123ノート

反応式

HRID 1827123 の反応式
Cl[C:2]1[N:7]=[N:6][C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.[H][H]>C(O)C.[Ni]>[N:7]1[CH:2]=[CH:3][CH:4]=[C:5]([NH:8][CH2:9][CH:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:17])[CH2:12][CH2:11]2)[N:6]=1

参加物

5

反応物 2

HCID 10155464HCID 10155464、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 9858528HCID 9858528、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

Benzyl 4-{[(6-chloro-3-pyridazinyl)amino]methyl}-1-piperidinecarboxylate (EXAMPLE 22) (400 mg, 1.11 mmol) was dissolved in absolute ethanol. Raney nickel (65 mg, 1.11 mmol) was then added and the resulting reaction was stirred under 1 atm hydrogen for 18 h. The catalyst was filtered and the filtrate was concentrated under reduced pressure. The resulting clear oil was purified by silica gel chromatography to give the title compound as a clear oil.

後処理

  1. customthe resulting reaction
  2. filtrationThe catalyst was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe resulting clear oil was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-ca28e54ade6b4ec6afeb50df6846c162
出典データセット
uspto-grants-2006_05
特許番号
US07053089B2

反応ノート

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