4-Ethyl-2-methylpyridine → HCID 11742250、化合物

反応式

C([C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[CH:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH:20][C:21]4[CH:32]=[CH:31][CH:30]=[CH:29][C:22]=4[C:23]([NH:25][CH2:26][C:27]#[CH:28])=[O:24])=[CH:17][CH:18]=3)[NH:13][N:12]=2)=[N:7][CH:8]=1)C.[CH2:33](C1C=CN=C(C)C=1)C.ClC1C=C2C(C(C(O)CC3C=CC(CC)=CN=3)=NN2)=CC=1.C1(N)CC1>>[CH:26]1([NH:25][C:23](=[O:24])[C:22]2[CH:29]=[CH:30][CH:31]=[CH:32][C:21]=2[NH:20][C:16]2[CH:15]=[C:14]3[C:19]([C:11](/[CH:10]=[CH:9]/[C:6]4[CH:5]=[C:4]([CH3:33])[CH:3]=[CH:8][N:7]=4)=[N:12][NH:13]3)=[CH:18][CH:17]=2)[CH2:27][CH2:28]1

参加物

反応物 4

HCID 683074-Ethyl-2-methylpyridine

HCID 69828Cyclopropylamine

HCID 86594461HCID 86594461、化合物

HCID 178436305HCID 178436305、化合物

生成物 1

HCID 11742250HCID 11742250、化合物

実験手順

The title compound was prepared analogously to 2-{3-[2-(5-Ethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-prop-2-ynyl-benzamide described above, substituting 2,4-dimethyl-pyridine for 4-ethyl-2-methyl-pyridine in the step where 1-(6-Chloro-1H-indazol-3-yl)-2-(5-ethyl-pyridin-2-yl)-ethanol was prepared, and substituting cyclopropyl amine in place of propargyl amine in the final step of the sequence. 1H NMR (DMSO-d6): δ 9.85 (1H, s), 8.56 (2H, m), 8.20 (3H, m), 7.53 (5H, m), 7.35 (1H, s), 7.2 (1H, d, J=6.5 Hz), 7.0 (1H, s), 2.83 (1H, m), 0.70 (2H, m), 0.56 (2H, m). ESIMS (M+H+): 410.3.

後処理

customwas prepared

出典と根拠

ORDレコード: ord-02603cba891b4f45af70d1b2575d2d08
出典データセット: uspto-grants-2006_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07053107B2

反応ノート

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