Propargylamine → HCID 178457679、化合物
反応式
[N:1]1([N:6]=[CH:7][C:8]2[C:16]3[C:11](=[CH:12][C:13]([NH:17][C:18]4[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=4[C:20](O)=[O:21])=[CH:14][CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH2:27]([NH2:30])[C:28]#[CH:29]>>[CH2:27]([NH:30][C:20](=[O:21])[C:19]1[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=1[NH:17][C:13]1[CH:12]=[C:11]2[C:16]([C:8]([CH:7]=[N:6][N:1]3[CH:2]=[CH:3][CH:4]=[CH:5]3)=[N:9][NH:10]2)=[CH:15][CH:14]=1)[C:28]#[CH:29]参加物
3
実験手順
Prepared in a similar manner to that described for Example 6 above, except using 2-[3-(Pyrrol-1-yliminomethyl)-1H-indazol-6-ylamino]-benzoic acid and propargylamine. 1H NMR (DMSO-d6) δ 13.30 (1H, s), 9.82 (1H, s), 9.04 (1H, t, J=5.6 Hz), 8.98 (1H, s), 8.19 (1H, d, J=8.6 Hz), 7.69 (1H, d, J=7.9 Hz), 7.45(4H, m), 7.31 (1H, s), 7.08 (1H, d, J=8.6 Hz), 6.91 (1H, t, J=7.6 Hz), 6.21 (2H, s), 4.05 (2H, s), 3.13 (1H, s). Anal. Calcd for C22H18N6O. 0.40H2O. 0.05 Hexanes: C, 67.97; H, 5.01; N, 21.33. Found: C, 67.91; H, 4.78; N, 21.00.
後処理
- customPrepared in a similar manner to that
出典と根拠
- ORDレコード
- ord-078ed1218a5c48f487ea740aaa2dd735