Triethylamine → 2-Cyano-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-benzenesulfonamide

HRID 1827549

反応式

HRID 1827549 の反応式
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH:24]4[CH2:29][CH2:28][CH2:27][CH2:26][O:25]4)[CH:18]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[C:37]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[S:45](Cl)(=[O:47])=[O:46])#[N:38].C(=O)(O)[O-].[Na+]>C(Cl)Cl>[C:37]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[S:45]([N:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][CH2:6][N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)=[CH:10][CH:11]=1)[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][O:25]2)[CH:18]=1)(=[O:47])=[O:46])#[N:38]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 516892Sodium BicarbonateHCID 5223472-Cyanobenzenesulfonyl ChlorideHCID 22137433HCID 22137433、化合物

生成物 1

HCID 221372832-Cyano-N-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-N-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-[3-(tetrahydro-pyran-2-yloxy)-benzyl]-amine (0.091 g, 0.23 mmol) and triethylamine (0.097 mL, 0.69 mmol) in 2 mL methylene chloride was added 2-cyanobenzenesulfonyl chloride (0.093 g, 0.46 mmol). The reaction mixture was stirred at room temperature for 24 hr. Saturated aqueous sodium bicarbonate was added and the layers were separated. The aqueous layer was washed with an additional 2 mL of methylene chloride. The combined organic layers were concentrated to afford the title compound of Step A.

後処理

  1. customthe layers were separated
  2. washThe aqueous layer was washed with an additional 2 mL of methylene chloride
  3. concentrationThe combined organic layers were concentrated

出典と根拠

ORDレコード
ord-b687e3e9f1574b49a08d89f017c2da74
出典データセット
uspto-grants-2006_05
特許番号
US07053212B2

関連ノート

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