Skatole → 7-chloro-1-methyl-1H-indole

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11]C1C2C(=CC=CC=2)NC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[CH:8]=[CH:7]2

参加物

反応物 2

HCID 6736Skatole

HCID 1046447-chloro-1H-indole

生成物 1

HCID 221391057-chloro-1-methyl-1H-indole収率 100%

実験手順

According to the procedure of Preparation 13 (a), except substituting 7-chloroindole for the 3-methylindole, the title compound (2.2 g, 100%) was obtained as a white solid: MS (ES) m/e 166.2 (M+H)+.

出典と根拠

ORDレコード: ord-e8f8388971ae40ecb68578a66714fe8a
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07741339B2

反応ノート

読み込み中…