1,3-dimethyl-1H-indole-2-carbaldehyde → 7-Chloro-N,1-dimethyl-1H-indole-3-methanamine

HRID 18279ノート

反応式

HRID 18279 の反応式
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[Cl:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[N:22]([CH3:24])[CH:21]=[C:20]2[CH:25]=O.CN1C2C(=CC=CC=2)C(C)=C1C=O>>[Cl:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[N:22]([CH3:24])[CH:21]=[C:20]2[CH2:25][NH:6][CH3:5]

参加物

4

反応物 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 221391467-chloro-1-methyl-1H-indole-3-carbaldehyde

生成物 1

HCID 221390677-Chloro-N,1-dimethyl-1H-indole-3-methanamine収率 93%

実験手順

According to the procedure of Preparation 13 (c), except substituting 7-chloro-1-methyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (2.0 g, 93%) was obtained as an amber oil: MS (ES) m/e 209.2 (M+H)+.

出典と根拠

ORDレコード
ord-8547a45da1974098a592e925e2e2f34f
出典データセット
uspto-grants-2010_06
特許番号
US07741339B2

反応ノート

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