Skatole → 5-Chloro-1-methylindole

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH3:11]C1C2C(=CC=CC=2)NC=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[CH:6]=[CH:5]2

参加物

反応物 2

HCID 6736Skatole

HCID 871105-Chloroindole

生成物 1

HCID 108558435-Chloro-1-methylindole収率 91%

実験手順

According to the procedure of Preparation 13 (a), except substituting 5-chloroindole for the 3-methylindole, the title compound (2.0 g, 91%) was obtained as an amber oil: MS (ES) m/e 166.0 (M+H)+.

出典と根拠

ORDレコード: ord-4b4f53c46a0e4246b4efa366e3273217
出典データセット: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07741339B2

反応ノート

読み込み中…