Sodium Bicarbonate → 4-Cyclobutyl-1,3-thiazol-2-amine

HRID 1828445ノート

反応式

HRID 1828445 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].Br[CH2:6][C:7]([CH:9]1[CH2:12][CH2:11][CH2:10]1)=O.C(=O)([O-])O.[Na+]>C(O)C>[CH:9]1([C:7]2[N:1]=[C:2]([NH2:4])[S:3][CH:6]=2)[CH2:12][CH2:11][CH2:10]1

参加物

5

反応物 3

HCID 516892Sodium BicarbonateHCID 2723790ThioureaHCID 110629402-Bromo-1-cyclobutylethan-1-one

生成物 1

HCID 220636344-Cyclobutyl-1,3-thiazol-2-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

Thiourea (2.3 g, 30.0 mmol) was dissolved in ethanol (100 ml), added with 2-bromo-1-cyclobutyl-1-ethanone synthesized in the same manner as in Example 1, (E), and then heated to 100° C. The reaction solution was stirred for 1 hour, then returned to room temperature, neutralized with saturated sodium hydrogencarbonate and extracted with chloroform. The collected organic layer was washed with saturated brine, dried over magnesium sulfate and then concentrated under reduced pressure. The title compound was obtained as the residue without purification as a brown oily substance (5.4 g, 100%).

後処理

  1. customsynthesized in the same manner as in Example 1, (E),
  2. customreturned to room temperature
  3. extractionextracted with chloroform
  4. washThe collected organic layer was washed with saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-e8187ae78d1c4a36845fb1374412f289
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

反応ノート

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