Dimethylformamide dimethyl acetal → Ethyl 3-(dimethylamino)-2-{2-[(4-methoxyphenyl)methyl]-2H-tetrazol-5-yl}prop-2-enoate
反応式
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH3:9][O:10][C:11]1[CH:28]=[CH:27][C:14]([CH2:15][N:16]2[N:20]=[N:19][C:18]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[N:17]2)=[CH:13][CH:12]=1>>[CH3:6][N:4]([CH3:5])[CH:3]=[C:21]([C:18]1[N:19]=[N:20][N:16]([CH2:15][C:14]2[CH:13]=[CH:12][C:11]([O:10][CH3:9])=[CH:28][CH:27]=2)[N:17]=1)[C:22]([O:24][CH2:25][CH3:26])=[O:23]参加物
3
反応条件
- 温度
- 100 °C
実験手順
Dimethylformamide dimethylacetal (13 ml, 97.3 mmol) was dissolved in ethyl 2-[2-(4-methoxybenzyl)-2H-1,2,3,4-tetrazol-5-yl]acetate (24 g, 88.4 mmol) and heated to 100° C. for 3 hours with stirring. The reaction solution was purified by silica gel column chromatography (hexane:ethyl acetate=3:1→1:1→1:3) to obtain 14 g (48%) of yellow crystals.
後処理
- custom