4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine → 8-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1828510ノート

反応式

HRID 1828510 の反応式
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].[CH3:18][O:19][C:20]1[CH:42]=[CH:41][C:23]([CH2:24][N:25]2[C:29]([CH:30]([C:36](OCC)=[O:37])[C:31](OCC)=[O:32])=[N:28][N:27]=[N:26]2)=[CH:22][CH:21]=1>BrC1C=CC=CC=1>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:31](=[O:32])[C:30]([C:29]4[N:25]([CH2:24][C:23]5[CH:41]=[CH:42][C:20]([O:19][CH3:18])=[CH:21][CH:22]=5)[N:26]=[N:27][N:28]=4)=[C:36]([OH:37])[N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 220636524-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridineHCID 22063755Diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate

生成物 1

HCID 1357244388-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-hydroxy-3-[(4-methoxybenzyl)tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one収率 71.7%

試薬・触媒・溶媒 1

HCID 7961Bromobenzene溶媒

実験手順

4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine (50 mg) and diethyl 2-[1-(4-methoxybenzyl)tetrazol-5-yl]malonate (141 mg) were heated to 150° C. in bromobenzene with stirring for 4 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (73 mg) as cream solid.

後処理

  1. customAfter the solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-e16a421f5eee48ed99d233754d116ddb
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

反応ノート

読み込み中…