Bromobenzene → ethyl (E)-3-{8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl}-2-propenoate
反応式
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH2:17])[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].CN([CH:21]=[C:22]([C:30](OCC)=[O:31])[CH:23]=[CH:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])C.BrC1C=CC=CC=1>>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][N:14]3[C:30](=[O:31])[C:22](/[CH:23]=[CH:24]/[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:21][N:17]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]参加物
4
反応条件
- 温度
- 160 °C
実験手順
4-[2-(4-Isopropyl-1,3-thiazol-2-yl)ethyl]-2-aminopyridine(200 mg), diethyl 4-dimethylaminomethyleneglutaconate (265 mg) was added with bromobenzene (2 ml) and heated at 120° C. for 1 hour and at 160° C. for 4 hours with stirring. The residue was purified by silica gel column chromatography to obtain the title compound (20 mg) as white powder.
後処理
- customThe residue was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-8e1ee26a48b34949bd410e20598ecf71
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- US07056917B2
反応ノート
読み込み中…