Acetic Anhydride → N-(4-methyl-5-nitropyridin-2-yl)acetamide

HRID 1828540

反応式

HRID 1828540 の反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH2:11])[CH:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>O>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 2431652-Amino-4-methyl-5-nitropyridine

生成物 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

4-Methyl-5-nitro-2-pyridinamine (3.69 g, 2.41 mmol) was added with acetic anhydride (10 ml) and stirred at 130° C. for 1.5 hours. The reaction mixture was left stand for cooling, and then added with distilled water (5.4 ml) at 0° C., heated to 130° C., and stirred for 45 minutes. The reaction mixture was left stand for cooling and concentrated, and the deposited crystals were collected by filtration and washed with distilled water to obtain the title compound (4.71 g, quantitative).

後処理

  1. waitThe reaction mixture was left stand
  2. temperaturefor cooling
  3. temperatureheated to 130° C.
  4. stirringstirred for 45 minutes
  5. waitThe reaction mixture was left stand
  6. temperaturefor cooling
  7. concentrationconcentrated
  8. filtrationthe deposited crystals were collected by filtration
  9. washwashed with distilled water

出典と根拠

ORDレコード
ord-ae1dc800dc2640f1a468cc2b45daad5f
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

関連ノート

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