N-(4-methyl-5-nitropyridin-2-yl)acetamide → N-(5-Amino-4-methylpyridin-2-yl)acetamide

HRID 1828541

反応式

HRID 1828541 の反応式
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([NH:11][C:12](=[O:14])[CH3:13])[CH:3]=1>C(O)C.[Pd]>[NH2:8][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH:11][C:12](=[O:14])[CH3:13])=[N:5][CH:6]=1

参加物

4

反応物 1

HCID 13567013N-(4-methyl-5-nitropyridin-2-yl)acetamide2 回

生成物 1

HCID 22063573N-(5-Amino-4-methylpyridin-2-yl)acetamide収率 103%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The N1-(4-methyl-5-nitro-2-pyridyl)acetamide (4.70 g, 24.1 mmol) obtained in (A) was dissolved in ethanol (150 ml), added with 10% palladium/carbon (0.95 g) and subjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere. The catalyst was removed by filtration and washed with ethanol. The filtrate was concentrated and the resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5) to obtain the title compound (4.10 g, quantitative) as brown solid.

後処理

  1. customsubjected to catalytic reduction overnight at 1 atm under hydrogen atmosphere
  2. customThe catalyst was removed by filtration
  3. washwashed with ethanol
  4. concentrationThe filtrate was concentrated
  5. customthe resulting residue was purified by silica gel column chromatography (chloroform chloroform:methanol=100:5)

出典と根拠

ORDレコード
ord-ef9681cf549f4b29a9a1e54462238dc5
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

関連ノート

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