Diethyl Ether → HCID 22063668、化合物

HRID 1828542

反応式

HRID 1828542 の反応式
[NH2:1][C:2]1[C:3]([CH3:12])=[CH:4][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[N:6][CH:7]=1.[N:13]([O-])=O.[Na+].C(OCC)C.[F:22][B-:23]([F:26])([F:25])[F:24].[H+]>>[F:22][B-:23]([F:26])([F:25])[F:24].[C:9]([NH:8][C:5]1[N:6]=[CH:7][C:2]([N+:1]#[N:13])=[C:3]([CH3:12])[CH:4]=1)(=[O:11])[CH3:10]

参加物

5

反応物 4

HCID 3283Diethyl EtherHCID 28118Tetrafluoroboric acidHCID 22063573N-(5-Amino-4-methylpyridin-2-yl)acetamide2 回HCID 23668193Sodium Nitrite

生成物 1

HCID 22063668HCID 22063668、化合物

反応条件

温度
-10 °C

実験手順

The N1-(5-amino-4-methyl-2-pyridyl)acetamide (8.00 g, 48.4 mmol) obtained in (B) was dissolved in tetrafluoroboric acid (160 ml) and slowly added dropwise with an aqueous solution (40 ml) of sodium nitrite (3.51 g, 50.8 mmol) at −20° C. under nitrogen atmosphere. The reaction mixture was further stirred at −10° C. for 1 hour and added with diethyl ether (800 ml), and the deposited white solid was collected by filtration and washed with diethyl ether to obtain the title compound (14.7 g, quantitative).

後処理

  1. filtrationthe deposited white solid was collected by filtration
  2. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-cbb21bec42474f60a019da7ee26d175a
出典データセット
uspto-grants-2006_06
特許番号
US07056917B2

関連ノート

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