関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Tetrafluoroboric acid | HCID 28118 | — |
| 反応物 | N-(5-Amino-4-methylpyridin-2-yl)acetamide | HCID 22063573 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 生成物 | 6-(Acetylamino)-4-methyl-3-pyridinediazonium tetrafluoroborate | HCID 22063668 | — |
反応手順
The N1-(5-amino-4-methyl-2-pyridyl)acetamide (8.00 g, 48.4 mmol) obtained in (B) was dissolved in tetrafluoroboric acid (160 ml) and slowly added dropwise with an aqueous solution (40 ml) of sodium nitrite (3.51 g, 50.8 mmol) at −20° C. under nitrogen atmosphere. The reaction mixture was further stirred at −10° C. for 1 hour and added with diethyl ether (800 ml), and the deposited white solid was collected by filtration and washed with diethyl ether to obtain the title compound (14.7 g, quantitative).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07056917B2 |
|---|
| 出典データセット | uspto-grants-2006_06 |
|---|
| ORD ID | ord-cbb21bec42474f60a019da7ee26d175a |
|---|
| 出典メモ | uspto-grants-2006_06 |
|---|
