関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbon tetrabromide | HCID 11205 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | [4-Cyclohexyl-3-(trifluoromethyl)phenyl]methanol | HCID 22057748 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Bromomethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene | HCID 22057749 | — |
反応手順
To a mixture of (4-cyclohexyl-3-trifluoromethyl-phenyl)-methanol (300 mg, 1.16 mmol) and PPh3 (460 mg, 1.74 mmol) in DCM (5 mL) at 0° C. is added CBr4 (580 mg, 1.74 mmol) dissolved in DCM (2 mL). The reaction is stirred at 0° C. for 1 h followed by concentration. The residue obtained is purified by silica gel chromatography (5% EtOAc in hexanes) to give 4-bromomethyl-1-cyclohexyl-2-trifluoromethyl-benzene as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07060697B2 |
|---|
| 出典データセット | uspto-grants-2006_06 |
|---|
| ORD ID | ord-30e006357a934be687f5293472599046 |
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| 出典メモ | uspto-grants-2006_06 |
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