N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamide → 3-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-3-oxopropanoic acid

反応式

C[O:2]C1C=C(NC(=O)C(O)=O)C=CC=1C1OC=NC=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH:33][C:34](=[O:46])[CH2:35][C:36](NC2C=CC=C(C)C=2)=[O:37])[CH:25]=[CH:26][C:27]=1[C:28]1[O:32][CH:31]=[N:30][CH:29]=1>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([NH:33][C:34](=[O:46])[CH2:35][C:36]([OH:37])=[O:2])[CH:25]=[CH:26][C:27]=1[C:28]1[O:32][CH:31]=[N:30][CH:29]=1

参加物

反応物 2

HCID 10361468N-(3-Methoxy-4-oxazol-5-yl-phenyl)-N''-m-tolyl-malonamide

HCID 22058527N-[3-methoxy-4-(5-oxazolyl)phenyl]oxalamic acid

生成物 1

HCID 220584973-[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]-3-oxopropanoic acid

実験手順

56A was prepared from 55 by a route analogous to that used for the preparation of 5A. LC/MS: ret. timeA=2.611 min., MS (M+H)+=277. 56B. Preparation of N-[3-Methoxy-4-(5-oxazolyl)phenyl]-N′-(3-methylphenyl) propanediamide

後処理

customtimeA=2.611 min., MS (M+H)+=277

出典と根拠

ORDレコード: ord-020bbbe10b584339bd7885048be34076
出典データセット: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07060720B2

反応ノート

読み込み中…

参加物