1-(2-chloro-4-(1-pentyloxy)benzyl)-4-ethenyl-2-methyl-1H-imidazole-5-carbaldehyde → 1-(2-chloro-4-(1-pentyloxy)benzyl)-4-ethyl-2-methyl-1H-imidazole-5-carbaldehyde

HRID 1828819ノート

反応式

HRID 1828819 の反応式
[Cl:1][C:2]1[CH:18]=[C:17]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:9]([CH:10]=[O:11])=[C:8]([CH:12]=[CH2:13])[N:7]=[C:6]1[CH3:14]>O1CCOCC1.[C].[Pd]>[Cl:1][C:2]1[CH:18]=[C:17]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[CH:16]=[CH:15][C:3]=1[CH2:4][N:5]1[C:9]([CH:10]=[O:11])=[C:8]([CH2:12][CH3:13])[N:7]=[C:6]1[CH3:14]

参加物

4

反応物 1

HCID 220586901-(2-chloro-4-(1-pentyloxy)benzyl)-4-ethenyl-2-methyl-1H-imidazole-5-carbaldehyde

生成物 1

HCID 220586571-(2-chloro-4-(1-pentyloxy)benzyl)-4-ethyl-2-methyl-1H-imidazole-5-carbaldehyde収率 48.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 312751,4-Dioxane溶媒

実験手順

1-(2-Chloro-4-(1-pentyloxy)benzyl)-4-ethenyl-2-methyl-1H-imidazole-5-carbaldehyde (575 mg) was dissolved in 1,4-dioxane (6 ml) and palladium carbon (50 mg) was added. The mixture was stirred under a hydrogen atmosphere for 1.5 hr. The reaction mixture was filtered through celite. Water was added to the filtrate and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was applied to silica gel column chromatography and eluted with chloroform/ethyl acetate=2/1. The objective fraction was concentrated under reduced pressure to give 1-(2-chloro-4-(1-pentyloxy)benzyl)-4-ethyl-2-methyl-1H-imidazole-5-carbaldehyde (283 mg) as a black brown oil.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. additionWater was added to the filtrate
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. washeluted with chloroform/ethyl acetate=2/1
  8. concentrationThe objective fraction was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-780b3400cac64ca7bf9d1775b0856bda
出典データセット
uspto-grants-2006_06
特許番号
US07060721B1

反応ノート

読み込み中…