Piperidine → 3-Cyclopropyl-4-[(4,5-dimethylpyrrol-2-yl)methylene]-2-pyrazolin-5-one
反応式
[CH:1]1([C:4]2[CH2:8][C:7](=[O:9])[NH:6][N:5]=2)[CH2:3][CH2:2]1.[CH3:10][C:11]1[CH:12]=[C:13]([CH:17]=O)[NH:14][C:15]=1[CH3:16].N1CCCCC1>C(O)C>[CH:1]1([C:4]2[C:8](=[CH:17][C:13]3[NH:14][C:15]([CH3:16])=[C:11]([CH3:10])[CH:12]=3)[C:7](=[O:9])[NH:6][N:5]=2)[CH2:3][CH2:2]1参加物
5
実験手順
A reaction mixture of 3-cyclopropyl-2-pyrazolin-5-one (790 mg, 6.3 mmol), 4,5-dimethylpyrrole-2-carboxaldehyde (800 mg, 6.5 mmol), and piperidine 100 mg, in ethanol 50 mL was stirred at 90° C. for 3.5 h. The solvent was removed under reduced pressure. The solid residue was purified by flash column chromatography using (3:7) ethyl acetate:hexane as the mobile phase, then further purified by recrystallization from toluene.
後処理
- customThe solvent was removed under reduced pressure
- customThe solid residue was purified by flash column chromatography
- customhexane as the mobile phase, then further purified by recrystallization from toluene
出典と根拠
- ORDレコード
- ord-727f2a5e88624356b4b60699002a4b69
- 出典データセット
- uspto-grants-2006_06
- 特許番号
- US07060822B1
反応ノート
読み込み中…