関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diethanolamine | HCID 8113 | — |
| 反応物 | 4-Chloro-2-(trifluoromethyl)quinoline | HCID 2736709 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline | HCID 22028887 | — |
反応手順
Diethanolamine (20 mL) was added to 4-chloro-2-trifluoromethylquinoline (5.04 g), and the mixture was stirred at 80° C. for 19 hr. Brine was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give 4-[N,N-bis(2-hydroxyethyl)amino]-2-trifluoromethylquinoline (3.40 g) as a white powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07060722B2 |
|---|
| 出典データセット | uspto-grants-2006_06 |
|---|
| ORD ID | ord-5a12686d5b184c17957184f36a38ae38 |
|---|
| 出典メモ | uspto-grants-2006_06 |
|---|
