Phosphorus oxychloride → 4-Chloro-2,6-bis(trifluoromethyl)quinoline

HRID 1829160ノート

反応式

HRID 1829160 の反応式
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[Cl:22][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]=[C:4]([C:16]([F:19])([F:18])[F:17])[CH:3]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 1785161332,6-Bis(trifluoromethyl)quinolin-4(1H)-one

生成物 1

HCID 6270374-Chloro-2,6-bis(trifluoromethyl)quinoline

実験手順

4-Hydroxy-2,6-bis(trifluoromethyl)quinoline (1.28 g) was dissolved in phosphorus oxychloride (5.0 mL), and the mixture was stirred at room temperature for 17 hr. The reaction mixture was concentrated under reduced pressure, and saturated aqueous sodium hydrogencarbonate solution was added to the residue. The mixture was extracted with chloroform and concentrated under reduced pressure to give 4-chloro-2,6-bis(trifluoromethyl)quinoline (1.17 g).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure, and saturated aqueous sodium hydrogencarbonate solution
  2. additionwas added to the residue
  3. extractionThe mixture was extracted with chloroform
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-405f0cdc792644d7a54e865f02a624b8
出典データセット
uspto-grants-2006_06
特許番号
US07060722B2

反応ノート

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