Acetic Anhydride → HCID 22061397、化合物

HRID 1829177ノート

反応式

HRID 1829177 の反応式
C(N(CC)CC)C.[C:8](OC(=O)C)(=[O:10])[CH3:9].[NH2:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:18]1>ClCCl>[C:8]([NH:15][CH2:16][CH:17]1[CH2:20][N:19]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:18]1)(=[O:10])[CH3:9]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 10679125Tert-butyl 3-(aminomethyl)azetidine-1-carboxylate

生成物 1

HCID 22061397HCID 22061397、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Triethylamine (0.76 ml, 5.45 mmol) and acetic anhydride (0.43 ml, 4.56 mmol) were added to an ice-cooled solution of tert-butyl 3-(aminomethyl)-1-azetidinecarboxylate (J. Med. Chem. 2001; 44(1); 94) (850 mg, 4.56 mmol) in dichloromethane (50 ml), and the reaction stirred for 30 minutes. The solution was washed with water (50 ml), brine (50 ml), dried (MgSO4) and evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel using ethyl acetate as eluant to afford the title compound as a yellow oil.

後処理

  1. washThe solution was washed with water (50 ml), brine (50 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated under reduced pressure
  4. customThe crude product was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-36e25a305e5142b2b161e92562b5576e
出典データセット
uspto-grants-2006_06
特許番号
US07060836B2

反応ノート

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