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1-Methyl-1H-indole-3-carbaldehyde → 2-chloro-1-methyl-2-(methylaminomethyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-1H-indole-3-carbaldehyde | HCID 87894 | — |
| 反応物 | 2-Chloro-1-methyl-1H-indole-3-carbaldehyde | HCID 314792 | — |
| 生成物 | 2-chloro-1-methyl-2-(methylaminomethyl)-1H-indole | HCID 66905063 | 90% |
反応手順
According to the procedure of Preparation 12, except substituting 2-chloro-1-methyl-1H-indole-3-carboxaldehyde (3.0 g, 15.5 mmole) for the 1-methylindole-3-carboxaldehyde, the title compound (2.91 g, 90%) was prepared as an oil: 1H NMR (400 MHz, CDCl3) δ 7.60 (d, J=7.9 Hz, 1 H), 7.22 (m, 2 H), 7.13 (m, 1 H), 3.92 (s, 2 H), 3.71 (s, 3 H), 2.44 (s, 3 H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741339B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-2ae7ea1641db4164a56859ad8f43adb2 |
| 出典メモ | uspto-grants-2010_06 |