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1-Propylethylenediamine → 5-Nitro-1H-indole-2-carboxylic acid (2-propylamino-ethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Propylethylenediamine | HCID 66073 | — |
| 反応物 | Ethyl 5-nitro-1H-indole-2-carboxylate | HCID 280312 | — |
| 反応物 | N-[2-(ethylamino)ethyl]-5-nitro-1H-indole-2-carboxamide | HCID 85801380 | — |
| 生成物 | 5-Nitro-1H-indole-2-carboxylic acid (2-propylamino-ethyl)-amide | HCID 85801385 | 85% |
反応手順
A similar procedure as described for preparation of 77 from 5-nitro-2-indolecarboxylic acid ethyl ester (0.8 g, 3.41 mmol) and N-propylethylenediamine (2 ml) gave a brown solid (0.84 g, 85%). ESI MS: 291.13 (M+H+). 1H NMR (DMSO-d6) δ 8.68 (d, 1H), 8.04 (d, 1H), 7.55 (d, 1H), 7.37 (s, 1H), 3.35 (m, 3H), 2.68 (q, 2H), 2.49 9 (q, 2H), 1.40 (tt, 2H), 0.84 (t, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07064218B2 |
| 出典データセット | uspto-grants-2006_06 |
| ORD ID | ord-9f46ccf9e1274fdd886f09938b88b301 |
| 出典メモ | uspto-grants-2006_06 |