4-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide → 4-[2-(5-Fluoro-1H-indazol-3-yl)-1-methyl-1H-benzimidazol-5-yloxy]-pyridine-2-carboxylic acid methylamide

HRID 1830017

反応式

HRID 1830017 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[CH:11]=O.[CH3:13][NH:14][C:15]([C:17]1[CH:22]=[C:21]([O:23][C:24]2[CH:29]=[CH:28][C:27]([NH:30][CH3:31])=[C:26]([NH2:32])[CH:25]=2)[CH:20]=[CH:19][N:18]=1)=[O:16]>>[CH3:13][NH:14][C:15]([C:17]1[CH:22]=[C:21]([O:23][C:24]2[CH:29]=[CH:28][C:27]3[N:30]([CH3:31])[C:11]([C:5]4[C:4]5[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=5)[NH:7][N:6]=4)=[N:32][C:26]=3[CH:25]=2)[CH:20]=[CH:19][N:18]=1)=[O:16]

参加物

3

反応物 2

HCID 177558384-(3-Amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamideHCID 178520032HCID 178520032、化合物

生成物 1

HCID 220560554-[2-(5-Fluoro-1H-indazol-3-yl)-1-methyl-1H-benzimidazol-5-yloxy]-pyridine-2-carboxylic acid methylamide

実験手順

The title compound was synthesized from 5-fluoro-1H-indazole-3-carbaldehyde and 4-(3-amino-4-methylamino-phenoxy)-pyridine-2-carboxylic acid methylamide as described above in Example 4. LC/MS (m/z) 417.4 (MH+), Rt 3.62 minutes.

出典と根拠

ORDレコード
ord-fc17fdce28a04c7eaa4645b8d916b12a
出典データセット
uspto-grants-2006_06
特許番号
US07064215B2

関連ノート

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