Ethanol → HCID 12084327、化合物

HRID 1830488ノート

反応式

HRID 1830488 の反応式
[CH:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])=[CH:2][CH3:3].C(O)C>[C].[Pd].C1(C)C=CC=CC=1>[CH2:1]([C:4]1[CH:16]=[CH:15][C:14]2[C:13]3[C:8](=[C:9]([F:17])[CH:10]=[CH:11][CH:12]=3)[CH2:7][C:6]=2[C:5]=1[F:18])[CH2:2][CH3:3]

参加物

5

反応物 2

HCID 702EthanolHCID 69530634HCID 69530634、化合物

生成物 1

HCID 12084327HCID 12084327、化合物収率 43.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 1140Toluene溶媒

実験手順

A mixture of 19.3 g of 2-(propen-1-yl)-1,8-difluorofluorene (K-3) (crude product), 1.5 g of 5% palladium-carbon, 80 ml of ethanol and 80 ml of toluene was hydrogenated over an 8 hour period at room temperature and under atmospheric pressure, with constant stirring. The palladium-carbon was removed by filtration, the solvent was removed from the filtrate by evaporation under reduced pressure, and the residue was then purified by silica gel column chromatography (hexane) to yield 8.5 g of 2-propyl-1,8-difluorofluorene (K-4).

後処理

  1. customThe palladium-carbon was removed by filtration
  2. customthe solvent was removed from the filtrate by evaporation under reduced pressure
  3. customthe residue was then purified by silica gel column chromatography (hexane)

出典と根拠

ORDレコード
ord-44b82ba1755b41a1aec090d99e648d21
出典データセット
uspto-grants-2006_06
特許番号
US07067179B1

反応ノート

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