4-Chloro-nicotinonitrile → 4-Methoxy-nicotinonitrile

HRID 1830859ノート

反応式

HRID 1830859 の反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:10][O-:11].[Na+].CO>CO>[CH3:10][O:11][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 134111124-Chloro-nicotinonitrileHCID 23694274Sodium methanolate methanol

生成物 1

HCID 27558874-Methoxy-nicotinonitrile収率 86%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of compound (20)(2.77 g, 20.0 mmol) in methanol (5 ml) was added a 28% sodium methylate-methanol solution (5.0 g, 24.0 mmol) at room temperature and the mixture was stirred for one hr. The solvent was concentrated and the obtained residue was partitioned between ethyl acetate and iced-brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The obtained residue was recrystallized from a small amount of isopropyl ether to give the title compound (2.3 g, 86%).

後処理

  1. concentrationThe solvent was concentrated
  2. customthe obtained residue was partitioned between ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. customthe solvent was evaporated under reduced pressure
  5. customThe obtained residue was recrystallized from a small amount of isopropyl ether

出典と根拠

ORDレコード
ord-0455b632e971400ca5ad7073ae0221fb
出典データセット
uspto-grants-2006_06
特許番号
US07067537B2

反応ノート

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