4-Vinylnicotinonitrile → 4-Ethylpyridine-3-carbonitrile

HRID 1830861ノート

反応式

HRID 1830861 の反応式
[CH:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)=[CH2:2]>C(OCC)(=O)C.[C].[Pd]>[CH2:1]([C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2]

参加物

4

反応物 1

HCID 220497874-Vinylnicotinonitrile

生成物 1

HCID 217660084-Ethylpyridine-3-carbonitrile収率 84%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

The compound (25) (0.73 g, 5.61 mmol) was dissolved in ethyl acetate (15 ml) and 10% palladium carbon (20 mg) was added. The mixture was stirred at normal temperature and normal pressure under a hydrogen atmosphere for 2 hrs. for hydrogenation. The reaction mixture was passed through celite and the filtrate was partitioned between ethyl acetate and brine. The aqueous layer was extracted with ethyl acetate, and the extract was combined and dried (MgSO4). The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give a colorless oil (0.62 g, 84%).

後処理

  1. customthe filtrate was partitioned between ethyl acetate and brine
  2. extractionThe aqueous layer was extracted with ethyl acetate
  3. dry with materialdried (MgSO4)
  4. customThe solvent was evaporated under reduced pressure
  5. customThe obtained residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-b925a0658e7f49edae20a39078f518b4
出典データセット
uspto-grants-2006_06
特許番号
US07067537B2

反応ノート

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